Compartmental loss of striatal medium spiny neurons in multiple system atrophy of parkinsonian type
Identifieur interne : 002F42 ( Main/Exploration ); précédent : 002F41; suivant : 002F43Compartmental loss of striatal medium spiny neurons in multiple system atrophy of parkinsonian type
Auteurs : Kenta Sato [Japon] ; Ryuji Kaji [Japon] ; Sadayuki Matsumoto [Japon] ; Shinji Nagahiro [Japon] ; Satoshi Goto [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-12-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Autopsy, Brain (pathology), Calbindins, Calcineurin (metabolism), Caudate Nucleus (pathology), Cell Count, Enkephalin, Methionine (metabolism), Female, Humans, Image Processing, Computer-Assisted, Immunohistochemistry, Male, Middle Aged, Multiple System Atrophy (metabolism), Multiple System Atrophy (pathology), Multiple system atrophy, Neostriatum (metabolism), Neostriatum (pathology), Nerve Degeneration (pathology), Nervous system diseases, Neuron, Neurons (metabolism), Neurons (pathology), Parkinson disease, Parkinsonian Disorders (metabolism), Parkinsonian Disorders (pathology), Putamen (pathology), S100 Calcium Binding Protein G (metabolism), matrix compartment, medium spiny neurons, multiple system atrophy, neurodegeneration, striosomes.
- MESH :
- chemical , metabolism : Calcineurin, Enkephalin, Methionine, S100 Calcium Binding Protein G.
- chemical : Calbindins.
- metabolism : Multiple System Atrophy, Neostriatum, Neurons, Parkinsonian Disorders.
- pathology : Brain, Caudate Nucleus, Multiple System Atrophy, Neostriatum, Nerve Degeneration, Neurons, Parkinsonian Disorders, Putamen.
- Aged, Autopsy, Cell Count, Female, Humans, Image Processing, Computer-Assisted, Immunohistochemistry, Male, Middle Aged.
Abstract
Topographical or compartmental involvement of the putamen and caudate nucleus has not been fully elucidated in multiple system atrophy predominantly presenting with Parkinsonism (MSA‐P). We carried out immunohistochemical studies using antibodies to calbindin (CALB) and calcineurin (CaN) as neurochemical markers for striatal medium spiny neurons. We found that in the caudal and dorsolateral putamen, the area most affected in MSA‐P, the medium spiny neurons positive for CALB were severely depleted, while CaN‐positive neurons were relatively spared in a mosaic pattern. In the dorsal caudate nucleus, an area less affected in MSA, residual CALB‐positive neurons exhibited a compartmentalized distribution that corresponded with the striosomal arrangement visualized by Met‐enkephalin immunostaining. Our findings suggest that there is a compartmental difference in the susceptibility of striatal medium spiny neurons to neurodegeneration in MSA‐P. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21732
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-12-15">2007-12-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="page" from="2365">2365</biblScope><biblScope unit="page" to="2370">2370</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">82103B476CDD49B822E975E1D817AD4061F0AD75</idno><idno type="DOI">10.1002/mds.21732</idno><idno type="ArticleID">MDS21732</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Autopsy</term><term>Brain (pathology)</term><term>Calbindins</term><term>Calcineurin (metabolism)</term><term>Caudate Nucleus (pathology)</term><term>Cell Count</term><term>Enkephalin, Methionine (metabolism)</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Immunohistochemistry</term><term>Male</term><term>Middle Aged</term><term>Multiple System Atrophy (metabolism)</term><term>Multiple System Atrophy (pathology)</term><term>Multiple system atrophy</term><term>Neostriatum (metabolism)</term><term>Neostriatum (pathology)</term><term>Nerve Degeneration (pathology)</term><term>Nervous system diseases</term><term>Neuron</term><term>Neurons (metabolism)</term><term>Neurons (pathology)</term><term>Parkinson disease</term><term>Parkinsonian Disorders (metabolism)</term><term>Parkinsonian Disorders (pathology)</term><term>Putamen (pathology)</term><term>S100 Calcium Binding Protein G (metabolism)</term><term>matrix compartment</term><term>medium spiny neurons</term><term>multiple system atrophy</term><term>neurodegeneration</term><term>striosomes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Calcineurin</term><term>Enkephalin, Methionine</term><term>S100 Calcium Binding Protein G</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Calbindins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Multiple System Atrophy</term><term>Neostriatum</term><term>Neurons</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Caudate Nucleus</term><term>Multiple System Atrophy</term><term>Neostriatum</term><term>Nerve Degeneration</term><term>Neurons</term><term>Parkinsonian Disorders</term><term>Putamen</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Autopsy</term><term>Cell Count</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Immunohistochemistry</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Atrophie multisystématisée</term><term>Maladie de Parkinson</term><term>Neurone</term><term>Pathologie du système nerveux</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Topographical or compartmental involvement of the putamen and caudate nucleus has not been fully elucidated in multiple system atrophy predominantly presenting with Parkinsonism (MSA‐P). We carried out immunohistochemical studies using antibodies to calbindin (CALB) and calcineurin (CaN) as neurochemical markers for striatal medium spiny neurons. We found that in the caudal and dorsolateral putamen, the area most affected in MSA‐P, the medium spiny neurons positive for CALB were severely depleted, while CaN‐positive neurons were relatively spared in a mosaic pattern. In the dorsal caudate nucleus, an area less affected in MSA, residual CALB‐positive neurons exhibited a compartmentalized distribution that corresponded with the striosomal arrangement visualized by Met‐enkephalin immunostaining. Our findings suggest that there is a compartmental difference in the susceptibility of striatal medium spiny neurons to neurodegeneration in MSA‐P. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Sato, Kenta" sort="Sato, Kenta" uniqKey="Sato K" first="Kenta" last="Sato">Kenta Sato</name></noRegion><name sortKey="Goto, Satoshi" sort="Goto, Satoshi" uniqKey="Goto S" first="Satoshi" last="Goto">Satoshi Goto</name><name sortKey="Kaji, Ryuji" sort="Kaji, Ryuji" uniqKey="Kaji R" first="Ryuji" last="Kaji">Ryuji Kaji</name><name sortKey="Matsumoto, Sadayuki" sort="Matsumoto, Sadayuki" uniqKey="Matsumoto S" first="Sadayuki" last="Matsumoto">Sadayuki Matsumoto</name><name sortKey="Nagahiro, Shinji" sort="Nagahiro, Shinji" uniqKey="Nagahiro S" first="Shinji" last="Nagahiro">Shinji Nagahiro</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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